Monitoring and Adapting Chemotherapeutic Interventions Using Diffuse Optics
Location:356 Fitzpatrick Hall
Despite an ever-increasing set of chemotherapeutic and targeted therapies for patients suffering from cancer, individual responses and resistance patterns remain highly variable. Standard-of-care imaging modalities (MRI, PET-CT, etc.) have limited ability to detect response and resistance early and often during treatment due to access, cost, and safety concerns. In order to move towards truly adaptive chemotherapeutic regimens, near real-time in vivo measurements of key response metrics are needed. Towards this goal, there has been significant interest in chemotherapy monitoring in breast cancer patients using diffuse optical technologies. Multiple groups, including ours, have demonstrated prognostic changes in endogenous chromophores after days, weeks or months of treatment. In order to translate these early findings to the standard of care, it is necessary to one. Validate optical signatures of treatment response and resistance in larger patient populations, 2. Screen unexplored treatment time points using new, more clinically versatile optical technologies, and three. Identify causative associations between specific molecular events and non-invasive optical signatures. In order to meet these challenges, our group is developing a variety of new clinical and preclinical diffuse optical measurement platforms including a new wearable continuous-wave infusion monitor and a portable all-digital frequency-domain Diffuse Optical Spectroscopy (DOS) system to access patients at the point-of-care including in the infusion suite and the doctor’s office. Additionally, in order to explore these rapid and early metabolic changes in a controlled preclinical setting, we are utilizing Spatial Frequency Domain Imaging (SFDI) and intra-vital multiphoton imaging to track treatment response and explore adaptive therapies in prostate and breast tumor models.
Professor Darren Roblyer
Darren Roblyer is an assistant professor in the Department of Biomedical Engineering at Boston University. His research is based on the development of near-infrared Diffuse Optical Spectroscopy (DOS) systems to both predict and better understand tumor response and resistance to chemotherapy in cancer patients and in preclinical models. After receiving a B.S. in Biomedical Engineering from Johns Hopkins University in 2004, Darren received his Ph.D. as a HHMI fellow in 2009 from the Bioengineering Department at Rice University where he studied under Professor Rebecca Richards-Kortum. Prior to starting his faculty position, Darren was a Department of Defense Postdoctoral Fellow at the Beckman Laser Institute at the University of California, Irvine studying under Professor Bruce Tromberg.